Effect and mechanism of quercetin or quercetin-containing formulas against COVID-19: From bench to bedside
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View abstract on PubMed
Summary
This summary is machine-generated.Quercetin shows potential benefits against COVID-19, but clinical evidence is currently weak. Further high-quality research is needed to confirm its effectiveness and improve its bioavailability for future applications.
Area Of Science
- Pharmacology and Translational Medicine
- Infectious Diseases
- Immunology
Background
- The COVID-19 pandemic, caused by SARS-CoV-2, is characterized by complex immunopathogenesis and thromboembolic events.
- Quercetin possesses documented antiviral, anti-inflammatory, immunomodulatory, antioxidative, and antithrombotic properties relevant to COVID-19.
- Existing reviews lack a comprehensive translational medicine perspective on quercetin's role in COVID-19.
Purpose Of The Study
- To comprehensively evaluate the existing basic and clinical evidence for quercetin's efficacy against COVID-19.
- To identify gaps in current research and guide future translational applications of quercetin and its derivatives.
Main Methods
- Systematic literature search of PubMed, Embase, and Cochrane Library databases.
- Inclusion of studies on COVID-19, SARS-CoV-2, and quercetin, covering antiviral, anti-inflammatory, immunomodulatory, and antithrombotic effects.
- Quality assessment of randomized controlled trials (RCTs) using the Cochrane Risk of Bias Tool (RoB 2).
Main Results
- Current clinical evidence supporting quercetin's effectiveness against COVID-19 is not robust, citing methodological flaws in existing trials.
- Low bioavailability and variable pharmacokinetics of quercetin present significant barriers to its clinical application.
- Evidence for quercetin's positive impact on immunomodulation via gut microbiota restoration is currently insufficient.
Conclusions
- Quercetin demonstrates potential therapeutic activities against COVID-19, but lacks strong clinical validation.
- Development of strategies to enhance quercetin's bioavailability and/or create effective derivatives is essential.
- Well-designed randomized controlled trials are crucial to establish the definitive efficacy of quercetin for COVID-19 treatment.
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