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H-type Hypertension Status and Influencing Factors of the Elderly People Over 80 Years Old Based on Random Forest

Xiaobo Zhang1,2, Botang Guo3, Hong Zhu4,5

  • 1Department of Cardiology Organization, The Second Affiliated Hospital, Harbin Medical University.

International Heart Journal
|March 13, 2024
PubMed

Insights

Identifying risk factors for H-type hypertension in the elderly is crucial. Ejection fraction (EF) is protective, while fibrinogen, HbA1c, and creatinine are risk factors in patients over 80.

Area of Science:

  • Gerontology
  • Cardiology
  • Clinical Medicine

Background:

  • Hypertension is a prevalent chronic condition in individuals over 80.
  • H-type hypertension is defined by coexisting hypertension and hyperhomocysteinemia (≥ 10 umol/L).
  • Identifying risk factors for H-type hypertension in the elderly is vital for improving patient outcomes.

Purpose of the Study:

  • To identify and analyze the risk factors associated with H-type hypertension in elderly patients (over 80 years old).
  • To provide insights for proactive intervention strategies to improve prognosis.

Main Methods:

  • A cohort of 494 hypertensive patients over 80 were divided into H-type (n=197) and non-H-type (n=297) groups.
  • Random forest and LASSO analyses were employed to screen potential influencing factors.
  • Multivariate stepwise regression analysis was used to validate the identified risk and protective factors.

Main Results:

  • The incidence of H-type hypertension in this elderly cohort was 39.88%.
  • Key factors identified included ejection fraction (EF), fibrinogen, glycated hemoglobin (HbA1c), creatinine, B-type natriuretic peptide, fasting blood glucose, uric acid, and serum triiodothyronine.
  • Multivariate analysis confirmed EF as a protective factor, while fibrinogen, HbA1c, and creatinine were significant risk factors (P < 0.05).

Conclusions:

  • Ejection fraction, fibrinogen, HbA1c, and creatinine levels are important indicators for assessing H-type hypertension risk in elderly patients.
  • Focusing on these factors allows for indirect assessment and proactive interventions.
  • These findings can guide healthcare professionals in providing targeted medical services to improve prognosis for elderly hypertensive patients.

Keywords:
CreatinineEjection fractionFibrinogenHbA1cRisk factors

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