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Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood

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[Pediatric aphereses (workshop SFGM-TC)].

Christian Chabannon¹, Malek Benakli², Kamelia Alexandrova³

¹Inserm CBT-1409 module biothérapies du centre d'investigations cliniques en biothérapies de Marseille, centre de thérapie cellulaire, institut Paoli-Calmettes, Aix-Marseille université, Marseille, France.

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Summary

Pediatric apheresis, especially for low-weight children, requires specialized training for healthcare staff. This ensures safety, product quality, and addresses unique clinical challenges in pediatric cell collection.

Keywords:

Apheresis Atelier d’harmonisation Cytaphérèse Greffe de cellules souches hématopoïétiques Guidelines Hematopoietic cell transplantation Pediatrics Practice harmonization workshop Pédiatrie Recommandations SFGM-TC

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Area of Science:

Pediatric Hematology
Cellular Therapy
Medical Training

Context:

Pediatric apheresis procedures differ significantly from adult practices.
Low patient volumes impact staff training and competency validation.
Caring for low-weight children presents unique procedural and clinical considerations.

Purpose:

To highlight the specialized training needs for pediatric apheresis.
To emphasize the critical aspects of managing low-weight pediatric patients during apheresis.
To underscore the necessity of multidisciplinary collaboration and formalized responsibilities.

Summary:

Pediatric apheresis requires specific training for healthcare personnel due to low procedure volumes and unique patient needs.
Key considerations include venous access, hemodynamic management, citrate toxicity, and stress minimization in low-weight children.
Effective pediatric apheresis necessitates a combined expertise from various healthcare teams and formalized inter-institutional protocols.

Impact:

Ensures enhanced safety for pediatric patients and healthcare staff during apheresis.
Improves the quality and specifications of collected cellular products for pediatric applications.
Establishes a framework for standardized, high-quality pediatric apheresis practices through collaborative efforts.