Related Experiment Video
Updated: Jul 1, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Elevated Plasma Lipoprotein(a) Level and Atherosclerotic Cardiovascular Disease Risks: A Large Clinical Retrospective
Kexin Wang1, Wenjie Wang1, Jialong Niu1
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, PR China.
Insights
Elevated lipoprotein(a) [Lp(a)] levels increase atherosclerotic cardiovascular disease (ASCVD) risk, even in patients with controlled low-density lipoprotein cholesterol (LDL-C). High Lp(a) with low LDL-C poses a significant ASCVD risk.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Atherosclerosis Research
Background:
- Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality.
- Despite controlled low-density lipoprotein cholesterol (LDL-C) levels, many patients experience ASCVD progression.
- The role of lipoprotein(a) [Lp(a)] as an independent ASCVD risk factor requires further elucidation.
Purpose of the Study:
- To investigate the association between elevated lipoprotein(a) [Lp(a)] levels and the risk of atherosclerotic cardiovascular disease (ASCVD).
- To analyze the combined impact of Lp(a) and LDL-C levels on ASCVD risk.
- To identify specific patient subgroups with elevated Lp(a) and increased ASCVD risk.
Main Methods:
- Retrospective analysis of 8070 ASCVD patients and 440 non-ASCVD participants.
- Multivariate logistic regression models to assess the relationship between lipid levels and ASCVD.
- Stratified analysis to evaluate ASCVD risk across different Lp(a) and LDL-C categories.
Main Results:
- Elevated lipoprotein(a) [Lp(a)] levels were identified as a significant independent risk factor for ASCVD (OR = 1.025, P < .001).
- Patients with high Lp(a) and low LDL-C exhibited a substantially higher ASCVD risk (OR = 9.612, P < .001) compared to those with low Lp(a) and high LDL-C.
- Increased ASCVD risk associated with elevated Lp(a) was observed in males, hypertensive, and diabetic patients.
Conclusions:
- Elevated lipoprotein(a) [Lp(a)] levels are independently associated with increased atherosclerotic cardiovascular disease (ASCVD) risk.
- Lipoprotein(a) is a critical risk factor, particularly in patients with low LDL-C.
- Targeting elevated Lp(a) may offer new therapeutic strategies for ASCVD prevention, especially in high-risk populations.
Abstract:
Patients with well-controlled low-density lipoprotein cholesterol (LDL-C) levels still suffer from the progress of the atherosclerotic cardiovascular disease (ASCVD) and can develop adverse outcomes. We conducted this study to analyze the relationship between elevated lipoprotein(a) [Lp(a)] levels and ASCVD risk. We enrolled 8070 patients in the ASCVD group and 440 participants in the non-ASCVD group [median age of 60 years; 6376 (74.9%) were male]. Multivariate logistic regression models were used to identify the relationships between the lipids and ASCVD. These models showed that the Lp(a) level was a significant independent risk factor for ASCVD [odds ratio (OR) = 1.025, confidence interval (CI) = 1.020-1.029, P < .001]. The different categories analysis showed the OR of the high Lp(a)/low LDL-C group was 9.612 [CI = 6.206-14.887], P < .001. Our study demonstrated that elevated Lp(a) levels were associated with the increased ASCVD risk. Also, the patients with low LDL-C but high Lp(a) levels still had a higher risk of developing ASCVD than the low Lp(a)/high LDL-C group. In addition, elevated Lp(a) levels were associated with a higher ASCVD risk in males, hypertensive, and diabetic patients.
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:18Lipids: Dietary Sources and Requirements
01:29Cholesterol: Significance and Regulation
Considering cholesterol and...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:31Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
01:38Inflammation