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Predictive value of the serum uric acid to high-density lipoprotein cholesterol ratio for culprit plaques in patients
Fuxue Deng1, Fang Jia2, Yang Sun1
1Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
BMC Cardiovascular Disorders
|March 14, 2024
Summary
The uric acid to HDL-C ratio (UHR) is linked to coronary culprit plaques in acute coronary syndrome (ACS) patients. An elevated UHR independently predicts plaque rupture, erosion, and thrombus, offering a simple detection biomarker.
Area of Science:
- Cardiology
- Biomarkers
- Atherosclerosis research
Background:
- Hyperuricemia and low high-density lipoprotein cholesterol (HDL-C) are established risk factors for coronary artery disease (CAD).
- The uric acid to HDL-C ratio (UHR) is a novel inflammatory and metabolic biomarker.
- The association between UHR and coronary culprit plaques in acute coronary syndrome (ACS) requires further investigation.
Purpose of the Study:
- To investigate the relationship between the uric acid to HDL-C ratio (UHR) and coronary culprit plaque characteristics in patients with ACS.
- To assess the predictive value of UHR for detecting culprit plaques.
Main Methods:
- A total of 346 patients with ACS were enrolled.
- Culprit lesion characteristics were evaluated using optical coherence tomography (OCT).
- Logistic regression, linear correlation, and receiver operating characteristic (ROC) curve analyses were employed.
Main Results:
- Higher UHR levels were associated with increased percentages of typical culprit plaques (ruptures, erosions, thrombi).
- UHR showed a positive correlation with diameter stenosis and area stenosis.
- UHR was independently associated with plaque rupture, erosion, and thrombus, demonstrating superior predictive value compared to low-density lipoprotein cholesterol.
Conclusions:
- Elevated UHR is independently linked to the presence of culprit plaques in ACS patients.
- The UHR serves as a simple and accessible biomarker for identifying culprit plaques in ACS.
- UHR offers a valuable tool for risk stratification and plaque detection in cardiovascular disease.
Keywords:
Acute coronary syndromeHigh-density lipoprotein cholesterolOptical coherence tomographyUric acidUric acid to HDL cholesterol ratioMore Related Videos
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