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Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
Published on: June 7, 2019
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Protein Kinase A in neurological disorders.
Alexander G P Glebov-McCloud1, Walter S Saide1, Marie E Gaine2,3
1Department of Neuroscience and Pharmacology, Bowen Science Building, University of Iowa, Carver College of Medicine, 51 Newton Road, Iowa City, IA, 52242, USA.
Journal of Neurodevelopmental Disorders
|March 14, 2024
Summary
Protein Kinase A (PKA) variants are linked to metabolic and neurodevelopmental disorders. This review explores cAMP/PKA signaling, PKA variants, and their distinct isoform-specific effects on cognitive function and endocrine health.
Area of Science:
- Molecular Biology
- Neuroscience
- Endocrinology
Background:
- Cyclic adenosine 3', 5' monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a crucial kinase regulating gene transcription, metabolism, and synaptic plasticity.
- Genomic studies reveal germline and somatic PKA variants in patients with metabolic and neurodevelopmental disorders.
Purpose of the Study:
- To review the classical cAMP/PKA signaling pathway.
- To discuss disease phenotypes associated with PKA variants.
- To highlight isoform-specific cognitive deficits and tissue distribution in neurodevelopmental disorders.
Main Methods:
- Literature review of genomic sequencing studies.
- Analysis of PKA signaling pathways.
- Correlation of PKA variants with disease phenotypes.
Main Results:
- PKA variants are implicated in both metabolic and neurodevelopmental conditions.
- Distinct isoform-specific cognitive deficits are observed in PKA subunit variants.
- Tissue-specific PKA isoform distribution may influence neurodevelopmental versus endocrine disorders.
Conclusions:
- PKA plays a significant role in diverse physiological processes.
- PKA variants contribute to a spectrum of human diseases.
- Isoform-specific functions of PKA subunits are critical for understanding neurodevelopmental disorders.
Keywords:
CREBCognitionEndocrine SystemsGene transcriptionKinasesLearningMAPKMemoryMetabolic DisordersMovement DisordersNeurodegenerationNeurodevelopmentPKAProtein phosphorylationcAMPMore Related Videos
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