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Bone pattern changes in post liver transplant patients using bisphosphonates.

Marcus Vinícius Bueno1, Luciana Munhoz2, Karem L Ortega3,4

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Summary
This summary is machine-generated.

Liver transplant patients on bisphosphonates show more bone sclerosis, increasing jaw osteonecrosis risk and reduced bone mineral density. This study highlights radiographic changes in these patients.

Keywords:
bisphosphonate‐associated osteonecrosis of the jawliver transplantationorgan transplantationosteoporosispanoramic radiographyradiography

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Area of Science:

  • Oral and Maxillofacial Radiology
  • Transplantation Medicine
  • Pharmacology

Background:

  • Bisphosphonates are commonly used to manage bone density loss in liver transplant recipients.
  • Osteonecrosis of the jaw (ONJ) is a potential complication associated with bisphosphonate use.
  • Radiographic assessment can aid in identifying early signs of bone changes.

Purpose of the Study:

  • To identify radiographic indicators of drug-induced osteonecrosis in liver transplant patients.
  • To evaluate radiomorphometric patterns related to bone mineral density changes in these patients.
  • To assess the association between bisphosphonate use and radiographic findings.

Main Methods:

  • Panoramic radiographs of liver transplant patients using bisphosphonates (study group) and those not using bisphosphonates (control group) were analyzed.
  • Radiographic parameters evaluated included mental index (MI), mandibular cortical index (MCI), and signs of osteonecrosis.
  • Statistical analysis compared the groups regarding bone mineral density (BMD) and bisphosphonate use.

Main Results:

  • A statistically significant decrease in bone mineral density (BMD) was associated with MCI-C3 (p=0.036).
  • No significant statistical results were found for MI in relation to BMD (p=0.14).
  • No valid statistical results linked MCI or MI with reduced BMD and bisphosphonate use.

Conclusions:

  • Liver transplant patients on bisphosphonates exhibit increased radiographic signs of bone sclerosis, suggesting a higher propensity for jaw osteonecrosis.
  • These patients also show an increased risk of reduced bone mineral density changes on panoramic radiographs.
  • Radiographic monitoring is crucial for early detection of these complications in liver transplant recipients on bisphosphonates.