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Related Concept Videos

Bone Remodeling01:40

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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Bone Pattern Changes In Post Liver Transplant Patients Using Bisphosphonates.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Bone Pattern Changes In Post Liver Transplant Patients Using Bisphosphonates.

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Bone pattern changes in post liver transplant patients using bisphosphonates.

Marcus Vinícius Bueno1, Luciana Munhoz2, Karem L Ortega3,4

  • 1Department of Dentistry, Central Institute, Clinical Hospital of Medical School of the University of São Paulo, São Paulo, SP, Brazil.

Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
|March 14, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Liver transplant patients on bisphosphonates show more bone sclerosis, increasing jaw osteonecrosis risk and reduced bone mineral density. This study highlights radiographic changes in these patients.

Keywords:
bisphosphonate‐associated osteonecrosis of the jawliver transplantationorgan transplantationosteoporosis

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Area of Science:

  • Oral and Maxillofacial Radiology
  • Transplantation Medicine
  • Pharmacology

Background:

  • Bisphosphonates are commonly used to manage bone density loss in liver transplant recipients.
  • Osteonecrosis of the jaw (ONJ) is a potential complication associated with bisphosphonate use.
  • Radiographic assessment can aid in identifying early signs of bone changes.

Purpose of the Study:

  • To identify radiographic indicators of drug-induced osteonecrosis in liver transplant patients.
  • To evaluate radiomorphometric patterns related to bone mineral density changes in these patients.
  • To assess the association between bisphosphonate use and radiographic findings.

Main Methods:

  • Panoramic radiographs of liver transplant patients using bisphosphonates (study group) and those not using bisphosphonates (control group) were analyzed.
panoramic radiography
radiography
  • Radiographic parameters evaluated included mental index (MI), mandibular cortical index (MCI), and signs of osteonecrosis.
  • Statistical analysis compared the groups regarding bone mineral density (BMD) and bisphosphonate use.

    • Main Results:

    • A statistically significant decrease in bone mineral density (BMD) was associated with MCI-C3 (p=0.036).
    • No significant statistical results were found for MI in relation to BMD (p=0.14).
    • No valid statistical results linked MCI or MI with reduced BMD and bisphosphonate use.

    Conclusions:

    • Liver transplant patients on bisphosphonates exhibit increased radiographic signs of bone sclerosis, suggesting a higher propensity for jaw osteonecrosis.
    • These patients also show an increased risk of reduced bone mineral density changes on panoramic radiographs.
    • Radiographic monitoring is crucial for early detection of these complications in liver transplant recipients on bisphosphonates.