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Inflammatory bowel disease activity threatens ankylosing spondylitis: implications from Mendelian randomization
Yimei Ding1, Jiaxu Chen1, Rouxin Li1
1Department of Rheumatology and Immunology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in Immunology
|March 14, 2024
Summary
Inflammatory bowel disease (IBD) significantly increases the risk of developing ankylosing spondylitis (AS). Active IBD further exacerbates this risk, highlighting the link between gut and joint inflammation.
Area of Science:
- Genetics and immunology
- Gastroenterology and rheumatology
Background:
- Inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) share inflammatory characteristics affecting the gut and joints.
- Epidemiological data suggest an increased incidence of AS in IBD patients, but causality and the role of IBD activity remain unclear.
Purpose of the Study:
- To investigate if IBD is a risk factor for AS development using Mendelian randomization.
- To explore the impact of IBD disease activity on the risk and progression of AS.
Main Methods:
- Two-sample Mendelian randomization (MR) analyses were performed across multiple datasets.
- Transcriptome analysis, including gene set enrichment and correlation analyses, was used to identify risk genes and pathways.
Main Results:
- MR analyses consistently showed that IBD significantly elevates the risk of AS.
- Higher risk scores and distinct molecular profiles (transcription factors, pathways, immune cells) were observed in active IBD patients.
- Seven immune cell types showed significant correlations with identified AS risk genes.
Conclusions:
- IBD is a significant risk factor for AS development.
- IBD activity demonstrably impacts the progression of AS, supported by combined MR and transcriptome data.
Keywords:
Mendelian randomizationankylosing spondylitisdisease activityinflammatory bowel diseasetranscriptome analysisMore Related Videos
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