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Chronic widespread pain and cause of death: a 25-year follow-up study

  • 0Spenshult Research and Development Center, Halmstad, Sweden.
Pain Reports +

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March 14, 2024

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March 14, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A stricter definition of chronic widespread pain (CWP) identifies individuals at higher risk of mortality, particularly from circulatory diseases. This highlights CWP as a significant clinical risk factor for increased mortality.

Area Of Science

  • Epidemiology
  • Public Health
  • Pain Medicine

Background

  • Chronic widespread pain (CWP) is linked to increased mortality from cardiovascular diseases and malignancies.
  • Discrepancies in CWP definitions hinder comparative study analysis.

Purpose Of The Study

  • To investigate if CWP increases mortality and specific causes of death.
  • To determine the impact of different CWP definitions on outcomes.

Main Methods

  • A 25-year follow-up study of 2425 individuals from the general population.
  • CWP defined using ACR1990 and WP2019 criteria.
  • Mortality analyzed using Cox regression, adjusted for confounders.

Main Results

  • The stringent WP2019 CWP definition showed significantly higher overall mortality (HR 1.32, P=0.033).
  • WP2019 CWP associated with increased circulatory disease mortality (HR 1.32, P=0.033) and deaths from infections and kidney failure.
  • ACR1990 CWP definition linked to increased digestive organ cancer mortality.

Conclusions

  • The WP2019 definition identifies a more vulnerable population group with excess mortality risk.
  • Chronic widespread pain, particularly as defined by WP2019, should be recognized as a clinical risk factor for mortality.

Keywords:

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