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Wenfei Guo1, Yuying Zhang1

  • 1School of Biological Science and Technology, University of Jinan, Jinan, China.

Frontiers in Oncology
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PubMed

Keywords:
ADAMTS18invasionmigrationprognosistumor microenvironment

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...