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Association of heart rate variability and C-reactive protein in patients with depression

Soni Singh1, Shraddha Singh1, Neeraja Shukla1

  • 1Department of Physiology, King George Medical University, Lucknow, Uttar Pradesh, India.

Journal of Family Medicine and Primary Care
|March 14, 2024
PubMed

Insights

Depression is linked to cardiovascular issues. This study found that certain heart rate variability (HRV) measures, indicating autonomic nervous system function, correlate with C-reactive protein (CRP) levels in depressed patients.

Area of Science:

  • Cardiology
  • Psychiatry
  • Physiology

Background:

  • Depression is associated with increased cardiovascular (CV) morbidity and mortality.
  • Inflammation and autonomic nervous system (ANS) dysfunction are implicated as potential contributing factors.
  • Existing research highlights links between inflammatory pathways and the ANS.

Purpose of the Study:

  • To investigate the relationship between heart rate variability (HRV) parameters and C-reactive protein (CRP) levels.
  • To explore these relationships in depressed patients without other concurrent diseases.

Main Methods:

  • A cross-sectional study involving 65 non-medicated depressed patients diagnosed via ICD-10 criteria.
  • Short-term HRV was recorded for 5 minutes using electrocardiogram (ECG).
  • C-reactive protein (CRP) levels were quantified using ELISA tests.

Main Results:

  • Heart rate variability (HRV) measures did not correlate with pulse rate, blood pressure, or BMI.
  • Positive correlations were observed between C-reactive protein (CRP) and very low frequency (VLF), low frequency (LF), and the LF/HF ratio of HRV.
  • Negative correlation was found between CRP and high frequency (HF) of HRV.

Conclusions:

  • Resting HRV and CRP measurements may aid in identifying CV disease risk in depressed individuals.
  • Low HRV and elevated CRP warrant prompt medical evaluation and management for cardiovascular risk.
Abstract

Keywords:
Autonomic nervous systemheart rate variabilityinflammationmajor depressive disorder

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