Related Experiment Video
Updated: Jul 1, 2025
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Biomarkers in allergen immunotherapy: Focus on eosinophilic inflammation
Chang-Keun Kim1, Zak Callaway1,2, Jin-Sung Park3
1Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea.
Abstract:
Asthma and allergic rhinitis (AR) are 2 of the most common chronic inflammatory disorders and they appear to be on the rise. Current pharmacotherapy effectively controls symptoms but does not alter the underlying pathophysiology. Allergen immunotherapy (AIT) is an evidence-based therapy for asthma and AR and has been recognized as the only therapeutic method that actually modifies the allergic disease process. There is a lack of objective markers that accurately and reliably reflect the therapeutic benefits of AIT. A biomarker indicating patients that would benefit most from AIT would be invaluable. Eosinophilic inflammation is a cardinal feature of many allergic diseases. Biomarkers that accurately reflect this inflammation are needed to better diagnose, treat, and monitor patients with allergic disorders. This review examines the current literature regarding AIT's effects on eosinophilic inflammation and biomarkers that may be used to determine the extent of these effects.
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