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Cancer-triggered systemic disease and therapeutic targets

Yihai Cao1

  • 1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, 171 65 Sweden.

Holistic Integrative Oncology
|March 14, 2024
PubMed

Insights

Cancer causes systemic diseases via metastasis, paraneoplastic syndromes (PNS), and cancer cachexia (CCA). This review explores mechanisms and treatments for overlooked PNS and CCA.

Area of Science:

  • Oncology
  • Systemic effects of cancer

Background:

  • Cancer induces systemic diseases through metastasis, paraneoplastic syndromes (PNS), and cancer cachexia (CCA).
  • While metastasis is well-researched, PNS and CCA are relatively overlooked.
  • Effective treatments for PNS and CCA in cancer patients are currently lacking.

Purpose of the Study:

  • To discuss mechanistic insights into paraneoplastic syndromes (PNS) and cancer cachexia (CCA).
  • To review current advances in the development of potential therapeutic interventions for PNS and CCA.

Main Methods:

  • Literature review focusing on the mechanisms of PNS and CCA.
  • Analysis of current research on therapeutic strategies for PNS and CCA.

Main Results:

  • PNS affects multiple organ systems (endocrine, gastrointestinal, hematologic, neurologic, dermatologic, ophthalmologic).
  • CCA is characterized by anorexia, progressive body weight loss, adipose, and muscle atrophy.
  • Mechanistic understanding of PNS and CCA is limited, hindering treatment development.

Conclusions:

  • Further research into the mechanisms of PNS and CCA is crucial.
  • Development of novel therapeutic interventions for PNS and CCA is urgently needed.
  • Addressing PNS and CCA can improve patient outcomes in cancer care.
Keywords:
Cancer cachexiaCancer therapyEndocrine disorderMetabolic diseaseParaneoplastic syndrome

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