Related Experiment Video
Updated: Jun 21, 2026
Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
Published on: February 6, 2020
Dynamic lymphocyte-CRP ratio as a predictor: a single-centre retrospective study on disease severity and progression
Dan Wang1, Yang Gao2, Qi-Qi Lai3
1Department of Anaesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Insights
Dynamic changes in the lymphocyte-C-reactive protein ratio (LCR) effectively differentiate COVID-19 severity and predict progression in adult patients. This ratio serves as a valuable prognostic marker for Coronavirus disease 2019 outcomes.
Area of Science:
- Infectious Diseases
- Clinical Medicine
- Biomarkers
Background:
- Coronavirus disease 2019 (COVID-19) presents a spectrum of severity.
- Accurate assessment of disease severity and progression is crucial for patient management.
- Novel biomarkers are needed to complement existing clinical scoring systems.
Purpose of the Study:
- To evaluate the efficacy of dynamic changes in the lymphocyte-C-reactive protein ratio (LCR) in differentiating COVID-19 disease severity.
- To assess the predictive value of LCR for disease progression in adult COVID-19 patients.
Main Methods:
- Retrospective single-centre study of 145 adult COVID-19 patients.
- Patients categorized into moderate, severe, and critical groups.
- Lymphocyte count and C-reactive protein (CRP) levels monitored, and LCR calculated at four time points.
- Sequential Organ Failure Assessment (SOFA) scores also recorded.
Main Results:
- Significant differences in demographic and clinical data, including LCR and SOFA scores, were observed across severity groups.
- Dynamic LCR changes showed significant differences between severity groups.
- LCR demonstrated a significant inverse correlation with COVID-19 disease severity (r values ranging from -0.429 to -0.564).
Conclusions:
- Dynamic changes in the lymphocyte-C-reactive protein ratio (LCR) are effective in differentiating COVID-19 disease severity.
- LCR serves as a valuable predictor of disease progression in adult patients with COVID-19.
Objective:
To assess the efficacy of dynamic changes in lymphocyte-C-reactive protein ratio (LCR) on differentiating disease severity and predicting disease progression in adult patients with Coronavirus disease 2019 (COVID-19).
Methods:
This single-centre retrospective study enrolled adult COVID-19 patients categorized into moderate, severe and critical groups according to the Diagnosis and Treatment of New Coronavirus Pneumonia (ninth edition). Demographic and clinical data were collected. LCR and sequential organ failure assessment (SOFA) score were calculated. Lymphocyte count and C-reactive protein (CRP) levels were monitored on up to four occasions. Disease severity was determined concurrently with each LCR measurement.
Results:
This study included 145 patients assigned to moderate (n = 105), severe (n = 33) and critical groups (n = 7). On admission, significant differences were observed among different disease severity groups including age, comorbidities, neutrophil proportion, lymphocyte count and proportion, D-Dimer, albumin, total bilirubin, direct bilirubin, indirect bilirubin, CRP and SOFA score. Dynamic changes in LCR showed significant differences across different disease severity groups at different times, which were significantly inversely correlated with disease severity of COVID-19, with correlation coefficients of -0.564, -0.548, -0.550 and -0.429 at four different times.
Conclusion:
Dynamic changes in LCR can effectively differentiate disease severity and predict disease progression in adult COVID-19 patients.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies