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A new wearable sensor array accurately detects multiple anticancer drugs in sweat, enabling personalized treatment and predicting side effects. This technology enhances anticancer drug monitoring for improved clinical outcomes.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Clinical Medicine

Background:

  • Concurrent anticancer drug use can improve efficacy but risks detrimental interactions.
  • Monitoring drug levels and toxicity is crucial for optimizing cancer therapy.
  • Simultaneous detection of multiple anticancer drugs refines potency and side effect assessment.

Purpose of the Study:

  • To design a wearable electrochemical aptasensor array for real-time monitoring of multiple anticancer drugs in sweat.
  • To evaluate the sensor array's accuracy, stability, and flexibility for clinical applications.

Main Methods:

  • Fabrication of a sensor array with aptamer-modified electrodes.
  • Molecular docking simulations to assess drug-aptamer binding affinities.
  • Square-wave voltammetry and multivariate data analysis for signal interpretation.

Main Results:

  • 100% accuracy in identifying nine anticancer drugs at uniform concentrations.
  • Successful differentiation of nine anticancer drugs in artificial sweat samples.
  • Demonstrated stability over 15 days and flexibility after 500 twisting cycles.

Conclusions:

  • The wearable aptasensor array offers a novel approach for real-time anticancer drug monitoring.
  • Enables precise adjustment of drug dosages and personalized cancer treatment.
  • Provides valuable insights for predicting drug efficacy and adverse reactions in clinical medicine.