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Integrated Electrochemical Aptasensor Array toward Monitoring Anticancer Drugs in Sweat
Xiaoyu Zhang1,2, Jiabing Zhang2,3, Ying Cai2
1Intelligent Agriculture Engineering Laboratory of Anhui Province, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
Abstract:
In the realm of clinical practice, the concurrent utilization of anticancer medications can enhance their overall therapeutic efficacy. However, it is crucial to acknowledge that the interactions among these anticancer drugs can potentially yield detrimental consequences on their intended outcomes. Consequently, the assessment of both anticancer potency and potential toxic side effects is greatly refined when multiple anticancer drugs are simultaneously detected and evaluated. Here, we designed a wearable electrochemical aptasensor array for monitoring multiple anticancer drugs in sweat. The integrated sensor array consists of three working electrodes modified with three different aptamers (Apt1, Apt2, and Apt3), a Au counter electrode, and a Ag/AgCl reference electrode. Molecular docking simulations were performed to show the binding affinities between three anticancer drugs and their corresponding aptamers. Various eigenvalues were derived from the square-wave voltammetry electrochemical signals, and these data sets were subjected to rigorous analysis through multivariate data analysis techniques. This analytical approach demonstrated exceptional performance by achieving flawless 100% accuracy in the precise identification of nine anticancer drugs consistently at uniform concentrations. Furthermore, the integrated wearable sensor array exhibited impressive capabilities, correctly recognizing all nine anticancer drugs with 100% accuracy and successfully distinguishing between these drugs in artificial sweat samples. The proposed sensor array presents good stability for 15 days. Flexibility tests showed stable device performance after 500 twisting cycles. This innovative wearable sensing array represents a novel approach for achieving real-time monitoring and precise adjustment of drug dosages. It offers invaluable insights for tailoring the treatment of anticancer drugs to individual patients, predicting both drug efficacy and potential adverse reactions within the field of clinical medicine.
Insights
A new wearable sensor array accurately detects multiple anticancer drugs in sweat, enabling personalized treatment and predicting side effects. This technology enhances anticancer drug monitoring for improved clinical outcomes.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Clinical Medicine
Background:
- Concurrent anticancer drug use can improve efficacy but risks detrimental interactions.
- Monitoring drug levels and toxicity is crucial for optimizing cancer therapy.
- Simultaneous detection of multiple anticancer drugs refines potency and side effect assessment.
Purpose of the Study:
- To design a wearable electrochemical aptasensor array for real-time monitoring of multiple anticancer drugs in sweat.
- To evaluate the sensor array's accuracy, stability, and flexibility for clinical applications.
Main Methods:
- Fabrication of a sensor array with aptamer-modified electrodes.
- Molecular docking simulations to assess drug-aptamer binding affinities.
- Square-wave voltammetry and multivariate data analysis for signal interpretation.
Main Results:
- 100% accuracy in identifying nine anticancer drugs at uniform concentrations.
- Successful differentiation of nine anticancer drugs in artificial sweat samples.
- Demonstrated stability over 15 days and flexibility after 500 twisting cycles.
Conclusions:
- The wearable aptasensor array offers a novel approach for real-time anticancer drug monitoring.
- Enables precise adjustment of drug dosages and personalized cancer treatment.
- Provides valuable insights for predicting drug efficacy and adverse reactions in clinical medicine.
