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Effectiveness of Tofacitinib in Patients With Ulcerative Colitis: A Nationwide Veterans Administration Cohort Study
Nabeel Khan1,2, Ramaswamy Sundararajan1, Manthankumar Patel1
1Department of Gastroenterology, Corporal Michael J Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
Introduction:
There is paucity of data on the effectiveness and safety of tofacitinib among elderly patients with ulcerative colitis (UC).
Methods:
Through a retrospective cohort study among the US National Veterans Affairs Healthcare System, we evaluated effectiveness among the elderly (≥65) and young (<65) patients with UC initiated on tofacitinib.
Results:
Among 158 patients (53 elderly, 105 young), effectiveness at 12 months was 50.94% in the elderly and 33.33% in the young ( P = 0.032).
Discussion:
In a nationwide cohort of patients with UC initiating tofacitinib, effectiveness was seen in half of the elderly patients.
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