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Updated: Jul 1, 2025

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
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Circadian and Diurnal Regulation of Cerebral Blood Flow

Alastair J S Webb1, Elizabeth B Klerman1,2,3,4, Emiri T Mandeville5

  • 1Department of Clinical Neurosciences, Wolfson Centre for Prevention of Stroke and Dementia, University of Oxford, United Kingdom (A.J.S.W.).

Circulation Research
|March 14, 2024
PubMed

Insights

Circadian rhythms influence cerebral blood flow, impacting stroke risk daily. Understanding these variations is key to stroke prevention, though cerebrovascular regulation needs more research.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Chronobiology

Background:

  • Cerebral blood flow (CBF) exhibits diurnal variations, influencing stroke risk.
  • CBF is regulated by systemic hemodynamics and cerebrovascular mechanisms.
  • These variations are linked to factors triggering stroke or impaired compensatory responses.

Purpose of the Study:

  • To review evidence on circadian and diurnal variations in CBF and its regulatory mechanisms.
  • To identify systemic hemodynamic and cerebrovascular factors contributing to diurnal stroke risk variation.
  • To highlight research gaps in understanding cerebrovascular regulation during diurnal fluctuations.

Main Methods:

  • Literature review of studies on circadian and diurnal variations in CBF.
  • Analysis of systemic hemodynamic factors (heart rate, cardiac output, blood pressure).
  • Evaluation of cerebrovascular regulatory mechanisms (reactivity, autoregulation, neurovascular coupling).

Main Results:

  • Diurnal variations in blood pressure, including nocturnal nadir and morning surge, are well-documented.
  • Evidence for circadian and diurnal variation in cerebrovascular compensatory mechanisms is limited.
  • Systemic hemodynamic factors are significantly related to diurnal stroke risk variation.

Conclusions:

  • Circadian and diurnal variations in CBF are critical determinants of stroke risk.
  • Further research is needed to elucidate the role of cerebrovascular regulatory mechanisms in diurnal stroke risk.
  • Understanding these temporal patterns is essential for developing effective stroke prevention strategies.

Keywords:
blood pressurecardiovascular diseasescerebrovascular circulationheart disease risk factorsrisk factors

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