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Diet composition impacts eQTL discovery across multiple tissues in baboons
Rachel M Petersen1, Amanda J Lea2
1Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA; Vanderbilt Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.
Abstract:
Understanding how genetic variation impacts gene expression is a major goal of genomics; however, only a fraction of disease-associated loci have been demonstrated to impact gene expression when cells are in an unperturbed "steady state." In this issue of Cell Genomics, Lin et al.1 investigate how exposure to a particular cellular context (i.e., a high-cholesterol, high-fat diet) can enhance our ability to identify new regulatory variants through longitudinal sampling of three tissue types in the baboon.
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