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Prospective association of comorbid hypertension and depressive symptoms with C-reactive protein in older adults

Chengwen Wang1, Shen Li2, Yunlong Song1

  • 1School of Education, Tianjin University, Tianjin, China; Institute of Applied Psychology, Tianjin University, Tianjin, China.

Journal of Affective Disorders
|March 14, 2024
PubMed

Insights

Comorbid hypertension and depressive symptoms increase the risk of elevated high-sensitivity C-reactive protein (hs-CRP) in older adults. This association is stronger in women and the elderly.

Area of Science:

  • Gerontology
  • Cardiovascular Health
  • Psychiatry

Background:

  • Hypertension and depressive symptoms frequently co-occur in older adults.
  • Both conditions have been independently linked to elevated C-reactive protein (CRP).

Purpose of the Study:

  • To investigate the prospective association between comorbid hypertension and depressive symptoms with high-sensitivity CRP (hs-CRP) levels.
  • To examine this relationship in a Chinese older population.

Main Methods:

  • Utilized data from 4978 participants aged 50+ from the China Health and Retirement Longitudinal Study (CHARLS) waves 2011 and 2015.
  • Measured hypertension, depressive symptoms, and hs-CRP.
  • Employed logistic regressions, adjusting for confounding variables, to assess the association between baseline comorbidity and hs-CRP change.

Main Results:

  • No independent association was found between hypertension or depressive symptoms alone and elevated hs-CRP.
  • Participants with comorbid hypertension and depressive symptoms showed a higher likelihood of elevated hs-CRP at follow-up (OR=1.39).
  • This association was more pronounced in women (OR=1.55) and older adults (OR=1.74).

Conclusions:

  • Comorbid hypertension and depressive symptoms are linked to an increased risk of elevated hs-CRP.
  • The association is more significant in women and older individuals.
Abstract

Keywords:
ComorbidityDepressive symptomsHs-CRPHypertension

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