3D MR elastography-based stiffness as a marker for predicting tumor grade and subtype in cervical cancer
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View abstract on PubMed
Summary
This summary is machine-generated.High tissue stiffness (TS) measured by 3D magnetic resonance elastography (MRE) can help differentiate cervical cancer (CC) subtypes and grades. This quantitative MRE parameter shows promise as a non-invasive biomarker for preoperative assessment of CC.
Area Of Science
- Biomedical Engineering
- Radiology
- Oncology
Background
- Increasing evidence suggests high tissue stiffness (TS) may indicate tumor aggressiveness.
- Accurate preoperative assessment of cervical cancer (CC) grade and subtype is crucial for effective treatment planning.
Purpose Of The Study
- To investigate the predictive value of magnetic resonance elastography (MRE)-based quantitative parameters for preoperative tumor grading and subtyping of cervical cancer (CC).
Main Methods
- A retrospective study involving 25 histopathology-proven CC patients and 7 healthy participants.
- 3.0T MRI with a three-dimensional spin-echo echo-planar imaging MRE sequence was utilized.
- Quantitative parameters including mean TS, storage modulus (G'), loss modulus (G″), and damping ratio (DR) were measured from regions of interest in tumors.
Main Results
- Tissue stiffness (TS) was significantly higher in endocervical adenocarcinoma (ECA) compared to squamous cell carcinoma (SCC) (5.27 kPa vs. 3.44 kPa, P=0.042).
- TS also differed significantly between poorly differentiated CC and well/moderately differentiated CC (5.21 kPa vs. 3.47 kPa, P=0.038), and between CC patients and healthy controls (4.18 kPa vs. 1.99 kPa, P<0.001).
- The area under the receiver operating characteristic curve (AUC) values for TS were 0.80 for discriminating ECA from SCC, 0.83 for poorly differentiated CC from well/moderately differentiated CC, and 0.88 for distinguishing normal cervix from CC.
Conclusions
- Three-dimensional MRE-assessed TS demonstrates potential as a preoperative biomarker for evaluating tumor grade and subtype in cervical cancer.
- Quantitative TS measurements may aid in non-invasively characterizing cervical lesions.
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