Identification of prognostic factors for survival in patients with metastatic gastric adenocarcinoma in a Mexican population
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View abstract on PubMed
Summary
This summary is machine-generated.The neutrophil-to-lymphocyte ratio (NLR), albumin levels, and performance status are key prognostic indicators for metastatic gastric cancer survival in Mexican patients. These factors aid in therapeutic decision-making for better patient outcomes.
Area Of Science
- Oncology
- Immunology
- Biochemistry
Background
- Gastric adenocarcinoma presents a significant global health challenge due to high incidence and mortality rates.
- Inflammation and immune responses are increasingly recognized as critical modulators of cancer progression and patient outcomes.
Purpose Of The Study
- To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and other clinical variables for overall survival in Mexican patients with metastatic gastric cancer.
- To identify independent predictors of survival to inform clinical decision-making.
Main Methods
- Retrospective analysis of 956 patients with metastatic gastric adenocarcinoma hospitalized between December 2011 and 2021.
- Calculation of NLR, PLR, albumin, and hemoglobin levels from blood samples.
- Assessment of functional status (ECOG, Karnofsky), sex, histology, and signet ring cell presence as potential prognostic factors.
- Univariate and multivariate analyses were employed to determine the prognostic significance of each variable.
Main Results
- An elevated NLR (>3.2) was associated with significantly lower survival rates (HR 1.51).
- Low albumin levels (<3.5 g/dL) and poor performance status (ECOG ≥2) were also independent predictors of reduced survival (HR 1.25 and HR 1.39, respectively).
- A Karnofsky score >70% correlated with improved survival (HR 0.69), while PLR did not show statistical significance.
Conclusions
- The neutrophil-to-lymphocyte ratio (NLR), serum albumin levels, and patient functional status (ECOG/Karnofsky) are significant independent prognostic factors for survival in metastatic gastric adenocarcinoma.
- These biomarkers can assist clinicians in therapeutic decision-making for this patient population.
- The findings highlight the importance of integrating inflammatory and nutritional markers into prognostic assessments for gastric cancer.
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