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Gastric inflammatory myofibroblastic tumor: a case report
Taku Hattori1, Yutaka Tanizawa2, Tadakazu Shimoda3
1Divisions of Gastric Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-Cho, Sunto-Gun, Shizuoka, 411-8777, Japan.
Surgical Case Reports
|March 15, 2024
Summary
Inflammatory myofibroblastic tumor (IMT) is a rare stomach neoplasm. This case highlights IMT as a possibility when encountering gastric submucosal tumors (SMTs).
Area of Science:
- Gastroenterology
- Surgical Pathology
- Oncology
Background:
- Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm affecting the stomach.
- Submucosal tumors (SMTs) of the stomach require careful differential diagnosis.
- This report details a specific case of gastric IMT presenting as an SMT.
Purpose of the Study:
- To present a case of gastric submucosal tumor (SMT) with a final diagnosis of inflammatory myofibroblastic tumor (IMT).
- To emphasize the importance of considering IMT in the differential diagnosis of gastric SMTs.
Main Methods:
- A 69-year-old male patient presented with a 24-mm gastric SMT.
- Diagnostic imaging included upper gastrointestinal endoscopy, contrast-enhanced computed tomography, and endoscopic ultrasonography-guided biopsy.
- Surgical resection was performed via laparoscopic-endoscopic cooperative surgery, followed by histopathological analysis.
Main Results:
- Preoperative biopsy did not yield a definitive histological diagnosis.
- Pathological examination revealed proliferative spindle cells positive for smooth muscle actin and negative for c-kit, desmin, s-100, CD34, STAT-6, β-catenin, and anaplastic lymphoma kinase 1.
- The final diagnosis was inflammatory myofibroblastic tumor (IMT) originating from the stomach.
Conclusions:
- Gastric inflammatory myofibroblastic tumor (IMT) should be considered in the differential diagnosis of gastric submucosal tumors (SMTs).
- Accurate preoperative diagnosis can be challenging, necessitating thorough histopathological evaluation.
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