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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Updated: Jun 30, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Time to Move Beyond a Binary Criterion for Gestational Diabetes?

Omran A H Musa1, Asma Syed1, Malkan A Khatib1

  • 1Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.

Reproductive Sciences (Thousand Oaks, Calif.)
|March 15, 2024
PubMed
Summary

A new NPRP criterion for diagnosing gestational diabetes mellitus (GDM) uses a single numerical summary of oral glucose tolerance test (GTT) readings. This approach aims to accurately diagnose GDM, reducing over- and under-diagnosis rates.

Keywords:
GDM CriteriaGDM DiagnosisGestational Diabetes

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Clinical Diagnostics

Background:

  • International guidelines for gestational diabetes mellitus (GDM) diagnosis lack consensus.
  • Current GDM diagnostic criteria risk over- or under-diagnosis of pregnant women.
  • Research was funded to address inconsistencies in GDM diagnosis.

Purpose of the Study:

  • To evaluate existing gestational diabetes mellitus (GDM) diagnostic criteria.
  • To introduce a novel diagnostic criterion for GDM.
  • To address the issue of over- and under-diagnosis in GDM.

Main Methods:

  • Development of a new diagnostic criterion (NPRP criterion) for GDM.
  • The NPRP criterion summarizes three oral glucose tolerance test (GTT) readings into a single numerical value.
  • Categorization of pregnant women into four glycemic levels: normal, impaired, GDM, and high-risk GDM.

Main Results:

  • Existing GDM criteria show minimal change, with a trend towards over-diagnosis.
  • The NPRP criterion unifies GTT readings into a single value.
  • The NPRP criterion classifies glycemic status into four distinct levels.

Conclusions:

  • The NPRP criterion offers a unified approach to GDM diagnosis.
  • This new criterion has the potential to mitigate over- and under-diagnosis of GDM.
  • Graded levels of dysglycemia in pregnancy are essential for accurate diagnosis.