RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.This study identifies five RNA modification-related genes (RMGs) as a prognostic signature for esophageal squamous cell carcinoma (ESCC). The gene NSUN6 was found to inhibit ESCC progression by regulating E-cadherin expression.
Area Of Science
- Oncology
- Molecular Biology
- Epigenetics
Background
- RNA modifications are increasingly linked to cancer development.
- The prognostic significance and functional roles of RNA modification-related genes (RMGs) in esophageal squamous cell carcinoma (ESCC) are not well understood.
Purpose Of The Study
- To establish a prognostic signature for ESCC using RMGs.
- To investigate the functional role and molecular mechanism of NSUN6 in ESCC progression.
Main Methods
- Development of a prognostic signature based on five RMGs.
- In vitro and in vivo experiments to assess NSUN6 function.
- Analysis of tRNA m5C modifications and CDH1 mRNA translation efficiency.
- Rescue assays to confirm downstream targets.
Main Results
- A five-gene RMG signature demonstrated prognostic value in ESCC.
- NSUN6 knockdown promoted ESCC progression, while overexpression inhibited it.
- NSUN6 enhances CDH1 mRNA translation efficiency via tRNA m5C modification.
- E-cadherin was identified as a key downstream mediator of NSUN6 function.
Conclusions
- The established RMG signature offers potential for ESCC prognosis.
- NSUN6 plays a critical role in regulating ESCC progression through E-cadherin.
- These findings provide insights into RMGs in ESCC and potential therapeutic strategies.
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