Related Experiment Video

Updated: Jun 30, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.3K

Identification of Circulating Plasma Proteins as a Mediator of Hypertension-Driven Cardiac Remodeling: A Mediation

Yuanlong Hu1, Lin Lin2, Lei Zhang3

  • 1First Clinical Medical College (Y.H., M.Z., J. Huan, Yunlun Li), Shandong University of Traditional Chinese Medicine, Jinan, China.

Hypertension (Dallas, Tex. : 1979)
|March 15, 2024
PubMed

Insights

This study identified specific plasma proteins that mediate hypertension's harmful effects on the heart. These findings advance our understanding of how high blood pressure leads to cardiac remodeling and heart failure.

Area of Science:

  • Cardiovascular Genetics
  • Proteomics
  • Medical Science

Background:

  • Hypertension causes significant myocardial remodeling and heart failure.
  • Identifying the specific mediators of this process is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the causal impact of blood pressure on cardiac traits using Mendelian randomization.
  • To identify plasma proteins that mediate the effects of blood pressure on cardiac remodeling and heart failure risk.

Main Methods:

  • A Mendelian randomization design was employed to assess the causal relationships.
  • Mediation analyses were conducted to pinpoint plasma protein mediators.
  • Cardiac magnetic resonance imaging traits and heart failure risk were evaluated.

Main Results:

  • Higher systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure were causally linked to increased left ventricular myocardial mass and altered wall thickness.
  • Specific plasma proteins, including fibroblast growth factor 5 (FGF5) and leptin, were identified as mediators.
  • FGF5 mediated the effects of SBP and DBP on myocardial wall thickness and heart failure susceptibility.

Conclusions:

  • This study provides evidence for specific circulating plasma proteins as key mediators of hypertension-driven cardiac remodeling.
  • The findings highlight potential therapeutic targets for preventing and treating hypertension-related heart conditions.
Abstract

Keywords:
blood pressureblood proteinsheart failurehypertensionventricular remodeling

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.5K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.1K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
81
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
428
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.6K