Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
The Stanford Prison Experiment03:20

The Stanford Prison Experiment

The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
Bullying02:04

Bullying

A modern form of aggression is bullying. As you learn in your study of child development, socializing and playing with other children is beneficial for children’s psychological development. However, as you may have experienced as a child, not all play behavior has positive outcomes. Some children are aggressive and want to play roughly. Other children are selfish and do not want to share toys. One form of negative social interactions among children that has become a national concern is bullying.
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Conduct Disorder01:28

Conduct Disorder

Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of Periodontal Abscesses and Endodontic-Periodontal Lesions-A Systematic Review.

Journal of clinical periodontology·2026
Same author

Factors affecting the efficacy of nonsurgical therapy of peri-implantitis.

Periodontology 2000·2026
Same author

Gingival and Periodontal Diseases and Conditions in Children and Adolescents: Consensus Report.

Journal of clinical periodontology·2026
Same author

Prosthetic Outcomes of Implant-Assisted Maxillary Restorations in the Edentulous Maxilla: A Systematic Review and Meta-Analysis.

Clinical oral implants research·2026
Same author

Tobacco Smoking and Smoke-Free Products as Risk Factors for Dental Implants: A Systematic Review.

Clinical oral implants research·2026
Same author

Consensus Report of Group 1 of the 1st Global Consensus for Clinical Guidelines for the Rehabilitation of the Edentulous Maxilla: Number of Implants, Timing of Implant Placement and Loading.

Clinical oral implants research·2026
Same journal

Effects of non-surgical periodontal therapy on intrabony periodontal defects at different re-evaluation time points: A systematic review of randomized controlled trials and clinical recommendations.

Periodontology 2000·2026
Same journal

Improving periodontal regeneration outcomes with hyaluronic acid: A systematic review and meta-analysis.

Periodontology 2000·2026
Same journal

Does adherence to supportive periodontal care lower the risk of caries and related tooth loss? A systematic review and meta-analysis.

Periodontology 2000·2026
Same journal

Long-term stability of periodontal plastic surgery featuring traditional autogenous graft and coronally advanced flap alone.

Periodontology 2000·2026
Same journal

Peri-implantitis-Is it mainly a clinician-initiated complication of implant therapy?

Periodontology 2000·2026
Same journal

Understanding exosomes in regenerative dentistry.

Periodontology 2000·2026
See all related articles

Related Experiment Video

Updated: May 16, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

28.7K

Differences between first- and second-generation autologous platelet concentrates.

Elena Calciolari1,2, Marina Dourou1, Aliye Akcali1,3

  • 1Centre for Oral Clinical Research, Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.

Periodontology 2000
|March 15, 2024
PubMed
Summary
This summary is machine-generated.

Autologous platelet concentrates (APCs), including platelet-rich plasma (PRP) and leukocyte and platelet-rich fibrin (L-PRF), enhance healing. Second-generation L-PRF offers a simpler, activator-free preparation compared to first-generation PRP.

Keywords:
L‐PRFPRGFPRPautologous platelet concentratesclassificationregenerative medicine

More Related Videos

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

2.5K
Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
05:57

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Published on: August 2, 2022

4.1K

Related Experiment Videos

Last Updated: May 16, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

28.7K
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

2.5K
Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
05:57

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Published on: August 2, 2022

4.1K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Hematology

Background:

  • Autologous platelet concentrates (APCs) are bioactive factors used in regenerative medicine to concentrate growth factors and cells for enhanced healing.
  • First-generation APCs, like platelet-rich plasma (PRP), require anticoagulants and activators, potentially interfering with natural healing.
  • Second-generation APCs, such as leukocyte and platelet-rich fibrin (L-PRF), avoid anticoagulants and activators, simplifying preparation.

Purpose of the Study:

  • To review and compare protocols for autologous platelet concentrate (APC) preparation.
  • To critically discuss differences between first-generation (PRP) and second-generation (L-PRF) APCs.
  • To highlight the need for standardized reporting in APC research for improved comparability and understanding.

Main Methods:

  • Review of documented protocols for APC preparations.
  • Critical discussion of differences in cell content, protein release, and fibrin network formation between PRP and L-PRF.
  • Analysis of limitations in current research reporting.

Main Results:

  • L-PRF preparation is simpler, less expensive, and avoids risks associated with activators compared to PRP.
  • Differences exist in cell composition, protein release kinetics, and the formation of a 3D fibrin matrix between APC generations.
  • Inconsistent reporting of protocol parameters hinders interpretation of APC efficacy and comparison of studies.

Conclusions:

  • Standardized classification and detailed reporting of APC preparation protocols are crucial for comparable study outcomes.
  • Further research is needed to clarify the mechanisms of action, including the role of leukocytes and centrifugation parameters.
  • Standardization will optimize the use of APCs in regenerative medicine.