Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Self-Growing and Mechanically Tunable Living Materials with <i>Paenibacillus mucilaginosus</i> Extracellular Polymeric Substances.

ACS applied polymer materials·2026

Same author

Silver Oxide Reduction Chemistry in an Alcohol Environment.

ACS omega·2026

Same author

Efficient Polaron Recombination and Fast Energy Transfer in a Deep Blue Phosphorescent Pt(II) Complex via Covalently Fused p-Type Host.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

BIC-Based Silicon Metasurfaces for Chiral Response and Tunable Chiral Absorption.

Nanomaterials (Basel, Switzerland)·2026

Same author

Optimization and interlaboratory validation of the HydroTouch test for fingertip-mediated microbial transmission and antimicrobial efficacy assessment of surfaces.

BMC microbiology·2026

Same author

Light-based 3D printing of mechanoluminescent living gels loaded with dinoflagellates.

Science advances·2026

Search research articles

Related Experiment Video

Updated: May 8, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications.

Qiyao Sun¹, Siyuan Tao², Giovanni Bovone³

¹Department of Health Science and Technology, ETH Zurich, Zurich, 8092, Switzerland.

Advanced Healthcare Materials

|March 15, 2024

Summary

Researchers developed tunable hydrogels using thermo-responsive polymers and nanocellulose. These biocompatible materials can be liquid for injection or solid for wound healing, offering controlled drug release and antimicrobial properties.

Keywords:

drug delivery hydrogel injectable nanocellulose wound dressing

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: May 8, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology

Background:

Hydrogels are versatile biomedical materials with tunable structural and mechanical properties.
Applications range from injectable formulations to solid wound-healing patches.
Controlling hydrogel properties is crucial for diverse biomedical applications.

Purpose of the Study:

To design a toolbox of biocompatible hydrogels with tunable mechanical properties.
To utilize thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) and nanocellulose.
To create injectable and solid-like hydrogels for various biomedical uses.

Main Methods:

Fabrication of hydrogels using thermo-responsive PNIPAM and nanocellulose.
Characterization of mechanical properties, including viscosity and viscoelasticity.
Assessment of biocompatibility and drug release kinetics.
Evaluation of antimicrobial efficacy of solid-like hydrogels.

Main Results:

Liquid hydrogels exhibited low viscosity and shear-thinning at 25°C for injection, becoming viscoelastic at body temperature.
Covalently cross-linked hydrogels showed enhanced viscoelasticity.
Liquid hydrogels demonstrated biocompatibility, delayed in vitro drug release, and maintained drug bioactivity.
Solid-like hydrogels loaded with antimicrobial agents were effective against wound pathogens.

Conclusions:

A simple method was developed to tune hydrogel mechanical strength for soft tissue applications.
Renewable bio-nanoparticles show potential in hybrid biomaterials for controlled drug delivery.
The developed hydrogels offer adaptable solutions for wound healing and drug delivery systems.