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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Biologic Therapy in Pediatric Chronic Rhinosinusitis: A Systematic Review.

Sara Rahavi-Ezabadi1, Sheng Zhou2, Stella E Lee3

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|March 15, 2024
PubMed
Summary

Limited research exists for biologic therapies in pediatric chronic rhinosinusitis with nasal polyposis (CRSwNP). While promising for the unified airway, more clinical trials are needed for broader use in children.

Keywords:
biologics childrenchronic rhinosinusitismAbnasal polypspediatricrhinosinusitis

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Area of Science:

  • Pediatric Otolaryngology
  • Immunology
  • Pharmacology

Background:

  • Chronic rhinosinusitis with nasal polyposis (CRSwNP) significantly impacts children's quality of life.
  • Biologic therapies have shown efficacy in adult CRSwNP and pediatric conditions like asthma and atopic dermatitis.
  • Evidence for biologic use in pediatric CRSwNP is currently limited.

Purpose of the Study:

  • To review the current evidence for biologic therapy in children diagnosed with CRSwNP.
  • To identify existing research and clinical trials investigating biologics for pediatric CRSwNP.
  • To assess the potential role of biologics in managing pediatric CRSwNP.

Main Methods:

  • A comprehensive literature search was conducted using PubMed, MEDLINE, Cochrane, and clinical trial registries.
  • Key search terms related to biologic therapy and pediatric CRSwNP were utilized.
  • The review focused on identifying studies and trials specifically addressing biologics in this population.

Main Results:

  • A significant lack of active clinical trials and research studies for biologics targeting pediatric CRSwNP was identified.
  • One ongoing compassionate-use trial for Dupilumab in children with nasal polyps was noted.
  • Only one published study specifically examined Dupilumab for pediatric CRSwNP in the context of aspirin-exacerbated respiratory disease.

Conclusions:

  • Current evidence for biologic therapy in pediatric CRSwNP is scarce.
  • Biologics show promise for managing the unified airway in children with CRSwNP.
  • Further Phase III clinical trials are essential to expand indications for biologics in pediatric CRSwNP, especially for those with comorbidities.