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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Histopathological, Clinical, And Molecular (hicam) Score For Patients With Colorectal Liver Metastases.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Histopathological, Clinical, And Molecular (hicam) Score For Patients With Colorectal Liver Metastases.

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Histopathological, Clinical, And Molecular (HICAM) score for patients with colorectal liver metastases.

Berta Martín-Cullell1,2,3, Anna C Virgili1,2,3, Pau Riera4,5

  • 1Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

The British Journal of Surgery
|March 15, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

The Genetic And Morphological Evaluation (GAME) score effectively predicts outcomes for colorectal liver metastases surgery. A new Histopathological, Clinical, And Molecular (HICAM) score shows promise for guiding adjuvant treatment post-resection.

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Cancer Prognostics

Background:

  • Validated prognostic tools for colorectal liver metastases are limited.
  • Histopathological and molecular features may offer prognostic insights.

Purpose of the Study:

  • To validate the Genetic And Morphological Evaluation (GAME) score for predicting prognosis in colorectal liver metastases.
  • To assess the impact of histological characteristics on patient outcomes after liver resection.
  • To develop a novel postoperative prognostic score (HICAM).

Main Methods:

  • Retrospective analysis of 176 patients with metastatic colorectal cancer undergoing liver resection.
  • Classification of patients based on the GAME score.
  • Calculation of relapse-free and overall survival.
  • Documentation of histopathological changes and development of the HICAM score.

    • Main Results:

    • The GAME score significantly differentiated high-risk from low-risk groups regarding relapse-free and overall survival (P=0.005).
    • A desertic immune phenotype was associated with worse overall survival (P=0.020).
    • The HICAM score also demonstrated significant prognostic value for relapse-free and overall survival (P<0.001).

    Conclusions:

    • The GAME score is validated as a reliable preoperative tool for selecting candidates for liver resection.
    • The HICAM score shows potential utility in guiding adjuvant treatment decisions following hepatic resection.