Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Production of Pharmaceuticals

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MBE for Surrey vet school professor.

The Veterinary record·2026

Same author

Going the extra mile: BVA Awards 2026.

The Veterinary record·2026

Same author

Great Britain's AI prevention zones lifted.

The Veterinary record·2026

Same author

RCVS announces its 2026 award winners.

The Veterinary record·2026

Same author

Illegal wildlife trade: the Facebook problem.

The Veterinary record·2026

Same author

Why are cats prone to kidney disease?

The Veterinary record·2026

Search research articles

Related Experiment Video

Updated: May 7, 2026

Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies

Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies

Published on: June 18, 2020

Creating PRRS-resistant pigs for the supermarket.

The Veterinary Record

|March 15, 2024

Summary

A UK company seeks US approval for pigs genetically modified for resistance to porcine reproductive and respiratory syndrome. This advancement could impact swine farming and disease control strategies globally.

Area of Science:

Veterinary Medicine
Animal Genetics
Disease Resistance

Background:

Porcine reproductive and respiratory syndrome (PRRS) poses a significant economic threat to the global swine industry.
Genetic modification offers a novel approach to developing PRRS-resistant livestock.
Regulatory approval processes are critical for the adoption of genetically engineered animals in agriculture.

Discussion:

The UK company's bid highlights the increasing interest in applying genetic engineering to address major animal diseases.
Assessing the safety and efficacy of PRRS-resistant pigs is paramount for regulatory bodies.
The potential market and implications for US swine production warrant careful consideration.

Key Insights:

Genetically engineered pigs are being developed to resist porcine reproductive and respiratory syndrome.

More Related Videos

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Author Spotlight: Exploring Cloning Techniques for Full-Length DNA Fragments

Author Spotlight: Exploring Cloning Techniques for Full-Length DNA Fragments

Published on: May 17, 2024

Related Experiment Videos

Last Updated: May 7, 2026

Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies

Production of Germ-Free Fast-Growing Broilers from a Commercial Line for Microbiota Studies

Published on: June 18, 2020

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Author Spotlight: Exploring Cloning Techniques for Full-Length DNA Fragments

Author Spotlight: Exploring Cloning Techniques for Full-Length DNA Fragments

Published on: May 17, 2024

A UK firm is pursuing US market approval for these PRRS-resistant swine.

This initiative represents a significant step in utilizing biotechnology for animal health.

Outlook:

Successful approval could pave the way for wider adoption of genetically modified animals in agriculture.
Further research into long-term impacts and public perception will be crucial.
International collaboration on regulatory frameworks for genetically engineered livestock may increase.