Related Experiment Video
Updated: Jun 30, 2025

14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
21.4K
Peer Comparison or Guideline-Based Feedback and Postsurgery Opioid Prescriptions: A Randomized Clinical Trial
Zachary Wagner1, Allison Kirkegaard1, Louis T Mariano2
1RAND Corporation, Santa Monica, California.
JAMA Health Forum
|March 15, 2024
Summary
Email feedback on opioid prescribing, based on either guidelines or peer comparison, effectively reduced excess prescriptions after surgery. These simple interventions may help curb downstream opioid misuse.
Area of Science:
- Clinical Medicine
- Public Health
- Health Services Research
Background:
- Excessive opioid prescribing post-surgery contributes to prolonged use and diversion.
- Social norm-based interventions show promise in modifying prescribing behaviors.
Purpose of the Study:
- To evaluate the effectiveness of two social norm-based interventions in reducing guideline-discordant opioid prescribing after surgical procedures.
Main Methods:
- A cluster randomized clinical trial involving 19 hospitals and 3 surgical specialties.
- Interventions included email feedback on prescribing relative to institutional guidelines or peer surgeons.
- A control group received no intervention; emails targeted surgeons with >2 guideline-discordant prescriptions.
Main Results:
- Guideline-discordant prescribing decreased from 36.8% in the control group to 27.5% (peer comparison) and 25.4% (guidelines).
- Peer comparison and guideline-based feedback interventions significantly reduced guideline-discordant prescribing by 5.8 and 4.7 percentage points, respectively.
- Intervention effects were most pronounced in surgeons with higher baseline prescribing rates and surgical volumes.
Conclusions:
- Email feedback interventions, whether guideline- or peer-based, effectively reduce post-surgical opioid prescribing that deviates from guidelines.
- These interventions are simple, low-cost, scalable, and have the potential to mitigate downstream opioid misuse.
- Guideline-based feedback demonstrated comparable effectiveness to peer comparison feedback.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
289
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
289
Analgesia and Pain Management
614
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
614
Opioid Analgesics: Morphine and Other Natural Cogeners
244
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
244

