Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

541
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
541
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

264
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
264
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K
Neural Regulation01:37

Neural Regulation

39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

475
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
475
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep brain stimulation of the subthalamic nucleus restores spatial reversal learning in patients with Parkinson's disease.

Brain communications·2024
Same author

α-Synuclein Pathology in PRKN-Linked Parkinson's Disease: New Insights from a Blood-Based Seed Amplification Assay.

Annals of neurology·2024
Same author

Does hyperphenylalaninemia induce brain glucose hypometabolism? Cerebral spinal fluid findings in treated adult phenylketonuric patients.

Molecular genetics and metabolism·2024
Same author

Turning alterations detected by mobile health technology in idiopathic REM sleep behavior disorder.

NPJ Parkinson's disease·2024
Same author

Effect of Thalamic versus Pallidal Deep Brain Stimulation on Head Tremor in Dystonic and Essential Tremor Patients-A Retrospective Video-Blinded Study.

Movement disorders clinical practice·2024
Same author

Longitudinal dynamics of depression in risk groups of older individuals during the COVID-19 pandemic.

Frontiers in epidemiology·2024

Related Experiment Video

Updated: Jun 30, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K

Defining Parkinson's Disease: Past and Future.

Kristina Kulcsarova1,2,3, Matej Skorvanek1,2, Ronald B Postuma4

  • 1Department of Neurology, P. J. Safarik University, Kosice, Slovak Republic.

Journal of Parkinson'S Disease
|March 15, 2024
PubMed
Summary

Parkinson's disease (PD) diagnosis is shifting from clinical symptoms to biological markers. Early detection through α-synuclein, neurodegeneration, and genetics aims for future disease-modifying therapies.

Keywords:
Parkinson’s diseasebiomarkersgeneticsneurodegenerationsynuclein

More Related Videos

Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

8.0K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.5K

Related Experiment Videos

Last Updated: Jun 30, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K
Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

8.0K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.5K

Area of Science:

  • Neurology
  • Neurodegenerative Diseases

Background:

  • Parkinson's disease (PD) is a progressive neurodegenerative disorder.
  • Current diagnostic criteria rely on late-stage motor symptoms, delaying intervention.
  • Understanding PD pathophysiology is crucial for early detection.

Purpose of the Study:

  • To review the evolution of Parkinson's disease definitions.
  • To advocate for a shift towards a biological definition of PD.
  • To explore early diagnostic markers for potential disease-modifying therapies.

Main Methods:

  • Literature review of PD diagnostic criteria and advancements.
  • Analysis of emerging biological markers for PD.
  • Discussion of the application of these markers in a biological PD definition.

Main Results:

  • Historical PD definitions were based on clinical motor signs.
  • A paradigm shift towards biological definitions is underway.
  • Key pillars for biological PD definition include α-synuclein aggregation, neurodegeneration, and genetics.

Conclusions:

  • A biological definition of PD, similar to Alzheimer's and Huntington's diseases, is proposed.
  • In vivo detection of specific markers can enable earlier PD diagnosis.
  • Early diagnosis is essential for developing and applying disease-modifying treatments.