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Decrease of drug resistance in Salmonella in the Netherlands.

W J van Leeuwen, J van Embden, P Guinée

Antimicrobial Agents and Chemotherapy

|August 1, 1979

Summary

Tetracycline resistance in Salmonella bacteria from humans and pigs has declined nationwide in The Netherlands since 1974. This reduction correlates with the prohibition of tetracycline in animal feed.

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Area of Science:

Veterinary Medicine
Microbiology
Public Health

Background:

Tetracycline antibiotics have been widely used in animal husbandry.
Antimicrobial resistance in bacterial pathogens is a significant global health concern.
Salmonella species are important foodborne pathogens affecting both humans and animals.

Purpose of the Study:

To investigate the trend of tetracycline resistance in Salmonella isolates from human and porcine sources in The Netherlands.
To assess the potential impact of the ban on tetracycline use in animal feed on resistance patterns.

Main Methods:

Retrospective analysis of Salmonella isolates collected nationwide.
Antimicrobial susceptibility testing, focusing on tetracycline resistance.
Correlation analysis between resistance trends and policy changes regarding tetracycline in animal feed.

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Main Results:

A significant nation-wide decrease in tetracycline resistance among Salmonella isolates of both human and porcine origin was observed.
The observed decline in resistance began around the time tetracycline was banned from animal feed.
This suggests a direct relationship between reduced antibiotic use in agriculture and decreased resistance.

Conclusions:

The ban on tetracycline in animal feed in The Netherlands has been effective in reducing tetracycline resistance in Salmonella.
Prudent antibiotic stewardship in animal agriculture can mitigate the development and spread of antimicrobial resistance.
Continued surveillance and policy enforcement are crucial for maintaining progress in combating antimicrobial resistance.