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Development of an immune-related diagnostic predictive model for oral lichen planus
Jiamin Bian1, Jiayu Yan1,2,3, Chu Chen2
1School of Stomatology, North Sichuan Medical College, Nanchong, Sichuan, China.
Medicine
|March 15, 2024
Summary
Researchers developed a new diagnostic model for oral lichen planus (OLP) using immune system data. This model, based on 5 key immune genes, aids in early OLP detection and potentially prevents cancer progression.
Area of Science:
- Immunology
- Genomics
- Computational Biology
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition with a known risk of malignant transformation.
- Immune system dysregulation is implicated in the pathogenesis of OLP.
- Early diagnosis and intervention are crucial for managing OLP and preventing cancer.
Purpose of the Study:
- To develop a diagnostic prediction model for OLP utilizing immunopathogenesis.
- To identify key immune-related biomarkers for early OLP detection.
- To provide insights for preventing OLP-associated malignancy.
Main Methods:
- Analysis of publicly available OLP gene expression datasets (GSE52130, GSE38616).
- Assessment of immune cell infiltration using MCPcounter and ssGSEA algorithms.
- Differential gene expression analysis, gene set enrichment analysis, and intersection with immunology databases (ImmPort).
- Construction of a diagnostic model using protein-protein interaction networks and LASSO regression.
Main Results:
- Significant immune cell infiltration observed in OLP compared to controls.
- Gene set enrichment analysis highlighted pathways related to keratinization, antibacterial, and immune responses.
- Identification of 774 differentially expressed genes, including 65 differentially expressed immunologically relevant genes (DEIRGs).
- A 5-hub gene (BST2, RNASEL, PI3, DEFB4A, CX3CL1) diagnostic model for OLP was established with good diagnostic accuracy.
Conclusions:
- The developed immune-related diagnostic model shows promise for early OLP detection.
- The 5 identified hub genes are potential biomarkers correlating with immune infiltration.
- This research offers a novel approach to understanding and diagnosing OLP, potentially aiding in cancer prevention.
