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Expression of β1- and β2-adrenergic receptors in oral squamous cell carcinoma and their association with

Ana Lívia Santos-Sousa1, Giseli Mitsuy Kayahara2, Daniela Brito Bastos1

  • 1Psychosomatic Research Center, Oral Oncology Center, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil.

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Summary

Psychological stress, including anxiety and fatigue, is linked to beta-adrenergic receptor (β-AR) expression in oral cancer. Advanced clinical stage correlates with lower β1-AR, while anxiety and fatigue predict higher β2-AR expression.

Keywords:
AnxietyBeta Adrenergic ReceptorsCancerDepressionImmunohistochemistryMood StateOral CancerPsychological DistressSquamous Cell CarcinomaStress

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Area of Science:

  • Oncology
  • Molecular Biology
  • Psychoneuroimmunology

Background:

  • Psychological stressors can influence tumor progression via beta-adrenergic receptors (β-AR).
  • Understanding β-AR expression in oral cancer is crucial for exploring stress-tumor interactions.

Purpose of the Study:

  • To investigate the expression of β1- and β2-adrenergic receptors (AR) in oral squamous cell carcinoma (OSCC).
  • To determine the association between β-AR expression and psychological/clinicopathological variables in OSCC patients.

Main Methods:

  • Immunohistochemistry was used to detect β1-AR and β2-AR expression in 99 OSCC tumor samples.
  • Psychological assessments included the Beck Anxiety Inventory, Beck Depression Inventory, and Brunel Mood Scale.

Main Results:

  • Higher β1-AR expression correlated with alcohol consumption, higher education, poor sleep, and increased pain.
  • Higher β2-AR expression was linked to regional metastasis, pain, anxiety, depression, anger, and fatigue.
  • Multivariate analysis showed advanced clinical stage was associated with lower β1-AR, while anxiety and fatigue predicted higher β2-AR.

Conclusions:

  • Anxiety, fatigue, and clinical stage are significantly associated with tumor β-AR expression in oral cancer.
  • These findings highlight the interplay between psychological factors, tumor biology, and clinical outcomes in OSCC.