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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Medication-associated orbital inflammation: A systematic review.

Terence Ang¹, Viraj Chaggar¹, Jessica Y Tong²

¹The University of Adelaide, Adelaide, South Australia, Australia.

Survey of Ophthalmology

|March 15, 2024

Summary

Medication-associated orbital inflammation, often affecting eye muscles, requires careful assessment. Promptly stopping the drug and using corticosteroids typically leads to good visual outcomes.

Keywords:

Dacryoadenitis Drug-associated Medication Medication-associated Myositis Orbital disease Orbital inflammation

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Area of Science:

Ophthalmology
Rheumatology
Pharmacology

Background:

Medication-associated orbital inflammation is an emerging clinical concern.
It can manifest as orbital myositis, dacryoadenitis, or orbital fat inflammation.
Exclusion criteria included isolated intraocular inflammation.

Purpose of the Study:

To systematically review and identify medication-associated orbital inflammation.
To characterize the clinical and radiological features of this condition.

Main Methods:

Systematic review of English-language literature up to June 2023.
Inclusion of articles detailing medication-associated orbital inflammation.
Exclusion of isolated intraocular inflammatory conditions.

Main Results:

Extraocular muscles are preferentially affected in medication-associated orbital inflammation.
Clinical and radiological features can be non-specific but may offer diagnostic clues.
Certain medications may be associated with specific patterns of inflammation.

Conclusions:

Medication-associated orbital inflammation is a critical differential diagnosis in orbital inflammatory disease.
Thorough medication history and clinical evaluation are essential for diagnosis.
Early drug cessation and appropriate management typically result in favorable visual prognosis.