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Related Experiment Video

Updated: Jun 30, 2025

Quantifying Intermembrane Distances with Serial Image Dilations

Quantifying Intermembrane Distances with Serial Image Dilations

Published on: September 28, 2018

Looking beyond blurred margins.

Jimmy S Chen¹, Bobby S Korn², Andrew R Carey³

¹Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.

Survey of Ophthalmology

|March 15, 2024

Summary

This summary is machine-generated.

A man experienced progressive vision loss due to neurosarcoidosis affecting his optic nerve. While steroids reduced inflammation, vision loss was irreversible, highlighting the importance of early diagnosis for optic nerve conditions.

Keywords:

Neurosarcoidosis Optic nerve biopsy Optic neuropathy Sarcoidosis

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Area of Science:

Neuro-ophthalmology
Neurology
Immunology

Background:

Neurosarcoidosis is a rare granulomatous disease that can affect the central nervous system.
Optic nerve involvement in neurosarcoidosis can lead to rapid and severe vision loss.

Observation:

A 60-year-old male presented with unilateral, progressive vision loss.
MRI revealed optic nerve and occipital lobe enhancement.
Optic nerve biopsy confirmed non-caseating granulomatous inflammation.

Findings:

The patient had no light perception in the affected eye.
Biopsy results were consistent with neurosarcoidosis.
High-dose steroids improved imaging findings but not vision.

Implications:

Early diagnosis and treatment are crucial for preserving vision in neurosarcoidosis.
Neurosarcoidosis should be considered in cases of unexplained optic neuropathy.
This case underscores the potential for irreversible vision loss despite treatment.