Deficits in olfactory system neurogenesis in neurodevelopmental disorders
Sean C Sweat1, Claire E J Cheetham1
1Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Genesis (New York, N.Y. : 2000)
|March 15, 2024
Summary
Neurogenesis, the creation of new neurons, is crucial for brain development. Disruptions in this process within the olfactory system may contribute to neurodevelopmental disorders (NDDs) like ADHD and autism.
Area of Science:
- Neuroscience
- Developmental Biology
Background:
- Neurogenesis is vital for nervous system development.
- The mammalian olfactory system exhibits postnatal neurogenesis, making it a valuable model.
- Disruptions in neurogenesis are implicated in neurodevelopmental disorders (NDDs).
Purpose of the Study:
- To review the role of neurogenesis disruption in the olfactory system concerning NDDs.
- To explore how olfactory system neurogenesis alterations contribute to NDD pathophysiology.
Main Methods:
- Literature review of studies on neurogenesis and NDDs.
- Analysis of research utilizing human, mouse, and Drosophila models.
- Focus on the olfactory system as a model for NDD investigation.
Main Results:
- Summarizes current knowledge on olfactory neurogenesis disruptions in NDDs.
- Highlights the connection between distinct neurogenesis stages and NDDs.
- Identifies specific NDDs linked to olfactory system neurogenesis issues: ADHD, ASD, Down syndrome, Fragile X, and Rett syndrome.
Conclusions:
- The olfactory system serves as a powerful model for studying NDDs.
- Continued investigation using the olfactory system can advance understanding of NDDs.
- Disruptions in neurogenesis stages within the olfactory system are relevant to NDDs.
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