Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected...

Area of Science:

• Cardiology
• Women's Health
• Menopause Research

Background:

• Cardiovascular diseases (CVD) are a leading cause of mortality in women.
• Early identification of high-risk individuals is crucial for effective management and improved clinical outcomes.
• Menopause is associated with an increased risk of cardiovascular events.

Purpose of the Study:

• To investigate the association between early menopause, abnormal diastolic function, and clinical outcomes in women.
• To identify potential risk markers for midlife cardiovascular events in women.

Main Methods:

• Retrospective analysis of 795 menopausal women from a nationwide registry.
• Patients were categorized into early (<45 years) and normal (≥45 years) menopause groups.
• Diastolic function was assessed, and multivariable-adjusted Cox models analyzed associations with major adverse cardiovascular events (MACE) over a median follow-up of 771 days.

Main Results:

• Early menopause was significantly associated with increased waist circumference, diabetes prevalence, obstructive coronary artery disease, and abnormal diastolic function.
• Women with early menopause experienced higher incidences of MACE, acute coronary syndrome, and heart failure hospitalization.
• In women with abnormal diastolic function, early menopause substantially increased MACE risk.

Conclusions:

• Early menopause and abnormal diastolic function are significant risk markers for cardiovascular events in women.
• These findings underscore the importance of monitoring women with early menopause and diastolic dysfunction for cardiovascular risk.
• Timely intervention strategies targeting these risk factors can potentially improve long-term cardiovascular health in women.