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  11. Prognostic Significance Of The Preoperative C-reactive Protein-albumin-lymphocyte (cally) Index On Outcomes After Gastrectomy For Gastric Cancer

Prognostic significance of the preoperative C-reactive protein-albumin-lymphocyte (CALLY) index on outcomes after gastrectomy for gastric cancer

Naoko Fukushima1,2, Takahiro Masuda3, Kazuto Tsuboi3,4

  • 1Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-Ku, Tokyo, 105-8461, Japan. naoko9037@gmail.com.

Surgery Today
|March 16, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

The preoperative C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index predicts outcomes in gastric cancer patients. A low CALLY index (<2) indicates a poorer prognosis after gastrectomy, highlighting its value in assessing patient survival.

Area of Science:

  • Oncology
  • Immunonutrition
  • Surgical Outcomes

Background:

  • Systemic inflammatory response markers are crucial prognostic indicators in cancer patients.
  • The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is an established immuno-nutritional scoring system.
  • Preoperative assessment of patient condition is vital for predicting surgical outcomes.

Purpose of the Study:

  • To investigate the prognostic impact of the preoperative CALLY index on patients undergoing gastrectomy for gastric cancer.
  • To determine if the CALLY index can predict overall survival (OS) and relapse-free survival (RFS) in gastric cancer patients.
  • To establish the CALLY index as a valuable tool in preoperative risk stratification for gastric cancer surgery.

Main Methods:

  • Analysis of data from 826 patients who underwent gastrectomy for stage I, II, or III gastric cancer (2010-2017).
Keywords:
C-reactive protein-albumin-lymphocyte indexGastrectomyGastric cancerSystemic inflammatory response

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  • Calculation of the CALLY index using the formula: (albumin × lymphocyte) / (CRP × 10⁴).
  • Statistical analysis, including multivariate analysis, to identify independent predictors of survival.

    • Main Results:

    • A preoperative CALLY index cutoff of 2 was established.
    • Patients with a CALLY index < 2 exhibited significantly worse OS and RFS compared to those with an index ≥ 2 (P < 0.01 for both).
    • Multivariate analysis confirmed that a CALLY index < 2, intraoperative blood loss, and advanced disease stage (II/III) were independent predictors of poorer RFS and OS.

    Conclusions:

    • The preoperative CALLY index is an independent predictor of poor prognosis in patients undergoing gastrectomy for gastric cancer.
    • The CALLY index serves as a valuable immuno-nutritional marker for assessing patient outcomes.
    • Incorporating the CALLY index into preoperative assessments may improve risk stratification and patient management.