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Musculoskeletal Organs-on-Chips: An Emerging Platform for Studying the Nanotechnology-Biology Interface
Yuwen Wang1, Patrick Yung2,3,4, Gang Lu2,5
1Department of Biomedical Engineering, The Chinese University of Hong Kong, NT, Hong Kong SAR, 999077, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|March 16, 2024
Summary
Organ-on-a-chip (OoC) systems combined with nanotechnology offer new ways to study musculoskeletal (MSK) disorders. This approach helps understand nanotechnology-biology interactions for better MSK disease management and personalized medicine.
Area of Science:
- Biomedical Engineering
- Materials Science
- Regenerative Medicine
Background:
- Musculoskeletal (MSK) disorders pose significant clinical challenges.
- Nanotechnology offers promising therapeutic strategies for MSK conditions.
- Clinical translation requires understanding nanotechnology-MSK biology interactions.
Purpose of the Study:
- To review advances in MSK organ-on-a-chip (OoC) systems.
- To explore the integration of nanotechnology within MSK OoCs.
- To highlight applications in disease mechanism analysis and drug development.
Main Methods:
- Review of recent literature on MSK OoCs and nanotechnology.
- Analysis of OoC capabilities in mimicking MSK tissue microenvironments.
- Integration of nanotechnology principles with OoC platforms.
Main Results:
- MSK OoCs can replicate key biophysical and biochemical stimuli.
- Integrating nanotechnology allows precise control of nanoscale environments.
- This enables detailed investigation of cellular responses and tissue behavior.
Conclusions:
- MSK OoCs with nanotechnology facilitate disease mechanism study and drug screening.
- Personalized medicine development for MSK disorders can be advanced.
- Future directions include enhanced sensing, immune integration, and biomimicry.
