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Frailty And Brain Changes In Older Adults Without Cognitive Impairment: A Scoping Review.

Home
Research Domains
Human Society
Gender Studies
Feminist Methodologies
Frailty And Brain Changes In Older Adults Without Cognitive Impairment: A Scoping Review.

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Frailty and brain changes in older adults without cognitive impairment: A scoping review.

Gabriela Cabett Cipolli¹, Isadora Cristina Ribeiro², Clarissa Lin Yasuda³

¹Postgraduate Program in Gerontology, College of Medical Sciences, State University of Campinas, Campinas, Brazil.

Archives of Gerontology and Geriatrics

|March 16, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Brain changes like white matter lesions and reduced brain volume are linked to frailty in older adults without cognitive impairment. These neuroimaging findings may aid early frailty detection.

Keywords:

Aged Aging Cerebrum Cognitive dysfunction

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Area of Science:

Neuroscience
Gerontology
Medical Imaging

Background:

Frailty is a growing concern in aging populations.
Understanding the neurological underpinnings of frailty, especially in cognitively unimpaired older adults, is crucial.

Purpose of the Study:

To conduct a scoping review of functional and structural brain changes in frail older adults without cognitive impairment.
To map existing evidence on brain alterations associated with frailty.

Main Methods:

Adherence to the Joanna Briggs Institute (JBI) methodology.
Comprehensive literature search across multiple databases (PubMed, Scopus, Web of Science, etc.) up to January 2023.
Screening and data extraction by two independent reviewers.

Main Results:

Common findings in frail individuals include white matter hyperintensities, reduced hippocampal and cerebellar volume, and decreased supplementary motor area connectivity.
Lower gray matter volume, cortical atrophy, and amyloid-beta peptide presence in specific brain regions (putamen, precuneus) were also noted.
These alterations suggest potential neurodegenerative or cerebrovascular origins.

Conclusions:

Neuroimaging studies reveal specific brain changes associated with frailty in older adults without cognitive impairment.
These findings enhance understanding of frailty's underlying mechanisms.
Implications for early frailty detection and intervention strategies are significant.