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Advances in Immunotherapy in Esophagogastric Cancer

Khalid Jazieh1, Harry Yoon1, Mojun Zhu1

  • 1Division of Medical Oncology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

Hematology/Oncology Clinics of North America
|March 16, 2024
PubMed

Insights

Immune checkpoint inhibitors, particularly anti-PD-1 therapy, show significant promise for esophagogastric cancer patients. This review covers key trials, challenges, and future directions for this evolving treatment landscape.

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Esophagogastric cancer treatment is evolving rapidly.
  • Immune checkpoint inhibitors (ICIs) represent a significant advancement.

Purpose of the Study:

  • To review the role of ICIs, specifically anti-PD-1 therapy, in esophagogastric cancer.
  • To discuss clinical trials, challenges, and future prospects.

Main Methods:

  • Literature review of landmark clinical trials.
  • Analysis of current challenges and opportunities in ICI therapy.
  • Exploration of future research directions.

Main Results:

  • Anti-PD-1 therapy shows promising efficacy in metastatic and resectable esophagogastric cancer.
  • Significant progress has been made, but challenges remain.

Conclusions:

  • ICIs, especially anti-PD-1 agents, are transforming esophagogastric cancer care.
  • Further research is needed to optimize treatment strategies and overcome resistance.
Keywords:
CancerEsophagealGastroesophagealImmune checkpoint inhibitorImmunotherapyMalignancyPD-1PD-L1

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