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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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  2. Wilkins Cr, Zwicker Ji, Derkach A, Burge M. Impact Of Romiplostim On Overall Survival In Chemotherapy Induced Thrombocytopenia. Blood. 2023;142(suppl 1):801-802
  1. Home
  2. Wilkins Cr, Zwicker Ji, Derkach A, Burge M. Impact Of Romiplostim On Overall Survival In Chemotherapy Induced Thrombocytopenia. Blood. 2023;142(suppl 1):801-802

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Wilkins CR, Zwicker JI, Derkach A, Burge M. Impact of romiplostim on overall survival in chemotherapy induced

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    |March 17, 2024

    View abstract on PubMed

    Summary
    This summary is machine-generated.

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    This study on growth factor administration in hematology has been retracted due to a reanalysis revealing similar survival between cohorts. The original conclusions were incorrect, prompting the retraction to prevent patient safety issues.

    Area of Science:

    • Hematology
    • Clinical Research
    • Patient Safety

    Background:

    • Original study investigated growth factor administration.
    • Initial conclusions suggested a difference in survival between cohorts.

    Purpose of the Study:

    • To report the retraction of a previously presented abstract.
    • To communicate the findings of a reanalysis of the study data.

    Main Methods:

    • Reanalysis of study cohorts.
    • Rematching cohorts based on platelet count at growth factor administration.

    Main Results:

    • Upon reanalysis, both cohorts displayed similar survival rates.
    • The revised findings differ substantially from the original abstract's conclusions.

    Conclusions:

    • The original conclusions were incorrect and potentially misleading.
    • Retraction is necessary to prevent patient safety issues.
    • All authors approved the retraction.