Four component Ugi reaction based small-molecule probes for integrated phenotypic screening
Manikandan Thangaraj1, Ksenia Lialin1, Rambabu Dandela2
1Department of Chemistry and The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev Be'er Sheva, Israel.
Bioorganic Chemistry
|March 17, 2024
Abstract:
Quorum-sensing (QS) is a cell density-dependent signaling pathway regulated by gene expression for intra- and interspecies communication. We have targeted QS activity in Pseudomonas aeruginosa, an opportunistic human pathogen that causes disease in immunocompromised patients, with a set of probes containing a variety of functional groups, including photoreactive (diazirine) and affinity (alkyne) moieties, that were synthesized using a four-component Ugi reaction (Ugi-4CR).
