Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simple algorithm for the solution of the multiple dosing problem.

S S Hacisalihzade

    Computer Methods and Programs in Biomedicine
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Computer analysis of eye movements.

    Computer methods and programs in biomedicine·1993
    Same author

    Schizophrenia, eye movements, and biocultural heterogeneity.

    Human biology·1990
    Same author

    Computer control systems and pharmacological drug administration: a survey.

    Journal of medical engineering & technology·1990
    Same author

    Behaviour space of a stretch reflex model and its implications for the neural control of voluntary movement.

    Medical & biological engineering & computing·1990
    Same author

    Effects of VDT resolution on visual fatigue and readability: an eye movement approach.

    Ergonomics·1989
    Same author

    Measuring parkinsonian symptoms with a tracking device.

    Computer methods and programs in biomedicine·1988

    This study presents a system theoretical approach to multiple dosing problems, reducing it to parameter optimization. An efficient algorithm and FORTRAN program are introduced and applied to Parkinson's disease treatment.

    Area of Science:

    • Pharmacokinetics and Pharmacodynamics
    • Systems Theory
    • Computational Biology

    Background:

    • Multiple dosing regimens are complex to optimize in clinical practice.
    • Parameter optimization offers a potential solution for dose regimen design.

    Purpose of the Study:

    • To develop a system theoretical approach for multiple dosing problems.
    • To introduce an efficient numerical algorithm and a user-friendly FORTRAN program for dose optimization.
    • To apply the developed methods to dopaminergic substitution therapy in Parkinson's disease.

    Main Methods:

    • A system theoretical framework was applied to the multiple dosing problem.
    • The problem was reduced to a classical parameter optimization task.
    • The cyclic coordinate search method was employed for numerical optimization.

    Related Experiment Videos

  • A FORTRAN program was developed for practical implementation.

    • Main Results:

    • The study successfully reduced the multiple dosing problem to parameter optimization.
    • An efficient numerical algorithm and a FORTRAN program were presented.
    • The methodology was validated through application to Parkinson's disease treatment, showing input and output data.

    Conclusions:

    • The system theoretical approach provides an effective framework for multiple dosing optimization.
    • The cyclic coordinate search algorithm and FORTRAN program offer a practical tool for clinical dose regimen design.
    • This approach has direct applicability to therapeutic challenges like Parkinson's disease.