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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
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Customizable orodispersible films: Inkjet printing and data matrix encoding for personalized hydrocortisone dosing.

Lucía Rodríguez-Pombo1, Paola Carou-Senra1, Erea Rodríguez-Martínez1

  • 1Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

International Journal of Pharmaceutics
|March 17, 2024
PubMed
Summary

Inkjet printing created personalized drug films with data matrices for safer medicine. This technology enhances drug delivery and accessibility in healthcare.

Keywords:
2D printed drug productsData-enriched edible pharmaceuticalsDesktop inkjet printingHydrocortisonePersonalized medicine

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Digital Health

Background:

  • Personalized medicine requires flexible and precise drug dosing.
  • Traditional drug formulation methods may not meet the needs of individualized treatments.
  • Innovations in manufacturing technologies are crucial for advancing pharmaceutical care.

Purpose of the Study:

  • To develop drug-loaded orodispersible films using inkjet printing technology.
  • To encode critical drug information within a data matrix pattern on the films.
  • To create specialized data matrix generator software for healthcare applications.

Main Methods:

  • Development and characterization of hydrocortisone (HC)-loaded pharma-inks.
  • Investigation of strategies to enhance HC solubility (e.g., β-cyclodextrin, Soluplus® micelles, co-solvents).
  • Utilizing custom software for automated data matrix generation and printing layer identification.

Main Results:

  • Successful preparation of flexible, low-dose, drug-loaded orodispersible films.
  • Co-solvent systems influenced drug solubility, ink viscosity, and surface tension.
  • β-cyclodextrin complexation improved drug deposition, while micelle-based inks were unsuitable for printing.
  • The developed software effectively adapted data matrix size and printing layers.

Conclusions:

  • Inkjet printing enables the creation of personalized, information-encoded drug delivery systems.
  • The specialized software enhances safety and accessibility in personalized medicine.
  • This approach offers a revolutionary advancement for tailored pharmaceutical treatments.