Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interleukin 6 Receptor Blockade for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

JAMA neurology·2026

Same author

Immune-mediated optic neuritis: A historical perspective.

Survey of ophthalmology·2026

Same author

Venous Sinus Stenting Outcomes in Patients with Papilledema from Secondary Causes of Elevated Intracranial Pressure.

Neuro-ophthalmology (Aeolus Press)·2026

Same author

Epiretinal membranes in multiple sclerosis: A window into glial pathobiology?

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Same author

The association between high-sensitivity C-reactive protein and depression symptom severity among U.S. adults: A multivariable analysis of NHANES data.

Brain, behavior, & immunity - health·2026

Same author

IL-6 Receptor Blockade as Rescue Therapy in Acute Attacks of MOGAD and AQP4+NMOSD.

JAMA neurology·2026

Search research articles

Related Experiment Video

Updated: Jun 30, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Paraneoplastic vision loss.

Deena Tajfirouz¹, John J Chen¹

¹Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States; Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Handbook of Clinical Neurology

|March 17, 2024

Summary

Paraneoplastic vision loss, a rare neurological syndrome, can cause blindness. Diagnosis is complex due to varied symptoms, but ocular tests help pinpoint the cause and guide treatment.

Keywords:

CRPM5 IgG Optic neuropathy Paraneoplastic Retinopathy Vision loss

More Related Videos

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Related Experiment Videos

Last Updated: Jun 30, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Area of Science:

Neuro-ophthalmology
Oncology
Immunology

Background:

Paraneoplastic vision loss is a rare but potentially blinding complication of cancer, often presenting with diverse visual symptoms.
It can manifest as optic neuropathy or retinopathy, frequently associated with specific antibodies like anti-CRMP5.
While often accompanied by other neurological signs, it can be the initial presenting symptom.

Approach:

Utilizing patient history, comprehensive ocular examinations, and diagnostic tools like automated perimetry, optical coherence tomography, and electroretinography.
Localizing vision loss to the optic nerves or retina is crucial for diagnosis and management.
Investigating associations with specific antibodies and paraneoplastic autoimmune retinopathies.

Key Points:

Variable visual symptoms and subacute, painless, bilateral presentation characterize paraneoplastic vision loss.
Anti-CRMP5 antibodies are commonly linked to paraneoplastic optic neuropathy.
Cancer-associated retinopathy, melanoma-associated retinopathy, and bilateral diffuse uveal melanocytic proliferation are key retinal manifestations.

Conclusions:

Advances in phenotypic characterization have improved understanding of paraneoplastic vision loss.
Further research is essential to identify reliable biomarkers.
Elucidating underlying mechanisms and optimizing management strategies remain critical areas for future study.